proteinaggregation相关论文
The epididymal lumen represents a unique extracellular environment because of the active sperm maturation process that t......
Objective.The enteric nervous system(ENS)control the function of gastrointestinal tract,such as gastrointestinal motilit......
Progressive accumulation of α-synuclein is a key step to pathological development of Parkinsons disease and dementia wi......
Entorhinal cortex(EC)is one of selectively vulnerable brain areas in normal aging and Alzheimers disease....
Requirement of Zn for ischemia-induced ubiquitin conjugation and protein aggregation in rat hippocam
The ubiquitin-proteasome system (UPS) is the major degradation pathway for intracellular proteins.The impairment and/or ......
Background and Purpose: Relative to the mature brain, the neonatal brain has shown increased resistance to hypoxia-ische......
Both glycosylation modification and GPI anchor can affect the subcellular localization of human prio
Transmissible spongiform encephalopathys(TSEs),also known as prion diseases,involve the accumulation of abnormally aggre......
Prion diseases are a group of fatal neurodegenerative diseases caused by the conformational changes of prion protein(PrP......
The cellular hallmarks of Parkinsons disease(PD)are the loss of nigral dopamine neurons and the formation of α-synuclei......
Zinc Enhances the Formation of Liquid and Hydrogel Phases of Human Tau and thereby Increases Tau Tox
The homeostasis of zinc is fundamentally important in the CNS to ensure many physiological processes,but dyshomeostasis ......
Neutralizing Mutations Significantly Inhibit Phase Separation of Human Prion Protein and Decrease It
Prion disease,such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy,is a kind of fatal neurodegenerativ......
Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length huma
A pathological hallmark of Alzheimer disease and other tauopathies is the formation of neurofibrillary tangles mainly co......
Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed m......
Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation s......
